Slc2a3 Gene Summary [Mouse]
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in D-glucose transmembrane transport and dehydroascorbic acid transport. Located in acrosomal membrane and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; early conceptus; and genitourinary system. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc2a3 |
| Official Name | solute carrier family 2 (facilitated glucose transporter), member 3 [Source:MGI Symbol;Acc:MGI:95757] |
| Ensembl ID | ENSMUSG00000003153 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 (facilitated glucose transporter), member 3 |
| Synonyms | GLUT1, GLUT3, LOC100909595, solute carrier family 2 (facilitated glucose transporter), member 3, solute carrier family 2 member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc2a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- benzoate transport
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- glucose binding
- phosphate:H+ symporter
- galactose transporter
- protein binding
- monosaccharide transporter
- organic anion transporter
- galactoside binding
- monosaccharide binding
- kinase binding
- Sugar (and other) transporter
- extracellular loop
- transporter
Pathways
Biological processes and signaling networks where the Slc2a3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometriosis
- glioblastoma cancer
- Alzheimer disease
- organismal death
- epileptic seizure
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- diabetic nephropathy
- papillary thyroid carcinoma
role in cell
- apoptosis
- activation in
- production in
- cell viability
- phosphorylation in
- expression in
- proliferation
- growth
- acidification in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- high-density microsomal fractions
- intracellular membrane fractions
- synaptic vesicle membrane
- aggresome
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- intracellular membranes
- cellular membrane
- endosomes
- vesicles
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- apical cell surfaces
- apical membrane
- caveolae
- synaptic membrane
- alpha granules
- acrosome
- synaptic vesicles
- cytoplasmic vesicles
- membrane rafts
- microvilli
- clathrin-coated vesicles
- parallel fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc2a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- dehydroascorbic acid transport
- glucose import
- L-ascorbic acid metabolic process
- galactose transport
- fructose transport
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- membrane
- perikaryon
- aggresome
- cell projection
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- glucose binding
- protein binding
- D-glucose transmembrane transporter activity
- dehydroascorbic acid transporter activity
- galactose transmembrane transporter activity
- fructose transmembrane transporter activity
- glucose transmembrane transporter activity