Ctu1 Gene Summary [Mouse]
Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Is expressed in brain. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctu1 |
| Official Name | cytosolic thiouridylase subunit 1 [Source:MGI Symbol;Acc:MGI:2385277] |
| Ensembl ID | ENSMUSG00000038888 |
| Bio databases IDs | |
| Aliases | cytosolic thiouridylase subunit 1 |
| Synonyms | ATPBD3, cytosolic thiouridylase subunit 1, NCS6, RGD1308740 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctu1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- TIGR00269 family protein
- protein binding
- zinc-ribbon
- Adenine nucleotide alpha hydrolase (AANH) superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctu1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA wobble uridine modification
- protein urmylation
- tRNA wobble position uridine thiolation
- tRNA thio-modification
Cellular Component
Where in the cell the gene product is active
- cytosol
- cytosolic tRNA wobble base thiouridylase complex
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- tRNA binding