Relt Gene Summary [Mouse]
Involved in amelogenesis. Predicted to be located in nucleoplasm. Is expressed in female associated reproductive structure and urethra of female. Used to study amelogenesis imperfecta type 3C. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3C. Orthologous to human RELT (RELT TNF receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Relt |
| Official Name | RELT tumor necrosis factor receptor [Source:MGI Symbol;Acc:MGI:2443373] |
| Ensembl ID | ENSMUSG00000008318 |
| Bio databases IDs | |
| Aliases | RELT tumor necrosis factor receptor |
| Synonyms | AI3C, E430021K24Rik, RELT TNF receptor, RELT, TNF receptor, RELT tumor necrosis factor receptor, RELT tumour necrosis factor receptor, TNFRSF19L, TRLT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Relt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
- Tumour necrosis factor receptor superfamily member 19
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amelogenesis imperfecta type IIIC
- amelogenesis imperfecta
- Ullrich congenital muscular dystrophy
regulates
- NFkB (complex)
role in cell
- proliferation
- apoptosis
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Relt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- amelogenesis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding