Zic3 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including axis specification; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within anterior/posterior pattern specification and heart looping. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; genitourinary system; and visual system. Used to study Goldenhar syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; visceral heterotaxy 1; and visceral heterotaxy 5. Orthologous to human ZIC3 (Zic family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zic3 |
| Official Name | zinc finger protein of the cerebellum 3 [Source:MGI Symbol;Acc:MGI:106676] |
| Ensembl ID | ENSMUSG00000067860 |
| Bio databases IDs | |
| Aliases | zinc finger protein of the cerebellum 3 |
| Synonyms | Bn, HTX, HTX1, Ka, RGD1561261, VACTERLX, Zic family member 3, zinc finger protein of the cerebellum 3, ZNF203 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zic3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- transcription co-activator
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc ribbon
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- Zic proteins zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Zic3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked visceral heterotaxy 1
- hypoplasia
- scoliosis
- growth failure
- hereditary disorder
- kyphosis
- vacterl with hydrocephalus, X-linked
- X-linked VACTERL association with or without hydrocephalus
- malocclusion
- X-linked multiple types congenital heart defects type 1
role in cell
- activation in
- differentiation
- expression in
- transactivation in
- cell cycle progression
- pluripotency
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zic3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system segmentation
- paraxial mesoderm development
- outer ear morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- face development
- axial mesoderm development
- neural plate development
- atrial cardiac muscle tissue development
- skeletal system development
- stem cell differentiation
- positive regulation of transcription, DNA-dependent
- heart looping
- determination of liver left/right asymmetry
- left/right axis specification
- lung development
- mRNA transcription from RNA polymerase II promoter
- neuron differentiation
- embryonic pattern specification
- determination of digestive tract left/right asymmetry
- smoothened signaling pathway
- hippocampus development
- determination of left/right symmetry
- central nervous system development
- germ-line stem cell maintenance
- limb morphogenesis
- primitive streak formation
- determination of left/right asymmetry in nervous system
- determination of pancreatic left/right asymmetry
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity