Orc5 Gene Summary [Mouse]
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Orc5 |
| Official Name | origin recognition complex, subunit 5 [Source:MGI Symbol;Acc:MGI:1347044] |
| Ensembl ID | ENSMUSG00000029012 |
| Bio databases IDs | |
| Aliases | origin recognition complex, subunit 5 |
| Synonyms | MmORC5, ORC5L, ORC5P, origin recognition complex subunit 5, origin recognition complex, subunit 5, PPP1R117 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- AAA ATPase domain
- DNA replication origin binding
- protein binding
- Origin recognition complex (ORC) subunit 5 C-terminus
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Pathways
Biological processes and signaling networks where the Orc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- major depression
- Waldenström macroglobulinemia
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- heterochromatic focus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication
- regulation of DNA replication
Cellular Component
Where in the cell the gene product is active
- origin recognition complex
- chromosome, telomeric region
- nucleus
- cytosol
- nuclear origin of replication recognition complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- ATP binding
- DNA replication origin binding
- protein binding