Strada Gene Summary [Mouse]
Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of intracellular protein-containing complex and serine/threonine protein kinase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Strada |
| Official Name | STE20-related kinase adaptor alpha [Source:MGI Symbol;Acc:MGI:1919399] |
| Ensembl ID | ENSMUSG00000069631 |
| Bio databases IDs | |
| Aliases | STE20-related kinase adaptor alpha |
| Synonyms | 2610019A05Rik, 6030402H20Rik, E130112C09Rik, LYK5, NY-BR-96, PMSE, STE20 related adaptor alpha, STE20 related adaptor α, STE20-related kinase adaptor alpha, STE20-related kinase adaptor α, Stlk, STRAD, STRAD alpha, STRAD α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Strada often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase binding
- binding protein
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Strada gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- PMSE syndrome
- benign rolandic epilepsy
- Alzheimer disease
role in cell
- phosphorylation in
- apoptosis
- accumulation in
- proliferation
- cell viability
- activation in
- accumulation
- G1 phase
- persistence time
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Strada gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G1 to G0 transition
- activation of protein kinase activity
- protein phosphorylation
- protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activator activity
- protein kinase activator activity
- protein kinase activity
- kinase binding