Sik2 Gene Summary [Mouse]
Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including protein phosphorylation; regulation of insulin receptor signaling pathway; and regulation of primary metabolic process. Acts upstream of or within insulin receptor signaling pathway; positive regulation of glycolytic process; and positive regulation of transcription from RNA polymerase II promoter by glucose. Located in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and heart. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sik2 |
| Official Name | salt inducible kinase 2 [Source:MGI Symbol;Acc:MGI:2445031] |
| Ensembl ID | ENSMUSG00000037112 |
| Bio databases IDs | |
| Aliases | salt inducible kinase 2 |
| Synonyms | G630080D20Rik, KIAA0781, LOH11CR1I, QIK, RGD1559698, salt-inducible kinase 2, SNF1LK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sik2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- hypertension
- epithelial cancer
- breast carcinoma
- asthma
- respiratory disorder
- primary sclerosing cholangitis
- prostatic carcinoma
role in cell
- apoptosis
- expression in
- degradation in
- binding in
- quantity
- phosphorylation in
- homeostasis
- fusion
- myogenesis by
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membranes
- Nucleus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sik2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- regulation of insulin receptor signaling pathway
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity