Capza1 Gene Summary [Mouse]
Contributes to actin filament binding activity. Acts upstream of or within barbed-end actin filament capping. Located in several cellular components, including brush border; cell-cell junction; and cortical cytoskeleton. Part of F-actin capping protein complex. Is expressed in early conceptus; head mesenchyme; and lung. Orthologous to human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capza1 |
| Official Name | capping protein (actin filament) muscle Z-line, alpha 1 [Source:MGI Symbol;Acc:MGI:106227] |
| Ensembl ID | ENSMUSG00000070372 |
| Bio databases IDs | |
| Aliases | capping protein (actin filament) muscle Z-line, alpha 1 |
| Synonyms | CAPPA1, capping actin protein of muscle Z-line subunit alpha 1, capping actin protein of muscle Z-line subunit α 1, CAPZ, capZ alpha-1, capZ α-1, CAZ1, CAZA1, LOC684096 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Capza1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- F-actin capping protein alpha subunit
- actin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- major depression
- neonatal late-onset sepsis
- diabetic nephropathy
- complete testicular feminization syndrome
- sickle cell anemia
- inguinal hernia
regulates
- CAPZA1
- actin
- G-actin
- ACTIN
- protein-protein complex
role in cell
- growth
- assembly
- actin capping
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cortical cytoskeleton
- cytoskeleton
- Extracellular Space
- cellular membrane
- actin cytoskeleton
- intercellular junctions
- cytosol
- brush border
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Capza1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- macromolecular complex assembly
- cell junction assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- actin cytoskeleton
- cytosol
- WASH complex
- extracellular region
- F-actin capping protein complex
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- cadherin binding