Vasp Gene Summary [Mouse]
Predicted to enable profilin binding activity. Acts upstream of or within actin cytoskeleton organization; axon guidance; and neural tube closure. Located in filopodium; focal adhesion; and lamellipodium. Is expressed in several structures, including adipose tissue; brain; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human VASP (vasodilator stimulated phosphoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vasp |
| Official Name | vasodilator-stimulated phosphoprotein [Source:MGI Symbol;Acc:MGI:109268] |
| Ensembl ID | ENSMUSG00000030403 |
| Bio databases IDs | |
| Aliases | vasodilator-stimulated phosphoprotein |
| Synonyms | vasodilator-stimulated phosphoprotein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vasp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ena VASP Homology 2
- F-actin binding domain
- WH2
- coiled-coil domain
- EVH1 domain
- protein binding
- Pleckstrin homology-like domain
- cGMP-dependent protein kinase phosphorylation site
- proline rich domain
- profilin binding
- VASP tetramerization domain
Pathways
Biological processes and signaling networks where the Vasp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- metastasis
- Marfan syndrome
- neonatal late-onset sepsis
- congenital malformation
- breast cancer
role in cell
- inhibition in
- expression in
- aggregation
- loss in
- number
- quantity
- formation
- formation in
- phosphorylation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- glutaminergic synapse
- minilamellipodium
- Cytoplasm
- cell-matrix contacts
- cell borders
- cell periphery
- postsynaptic region
- peripheral lamellae
- focal adhesions
- actin cytoskeleton
- actin filaments
- cell-cell contacts
- cytosol
- membrane ruffles
- cell membrane-lagging edges
- microfilaments
- actin stress fibers
- membrane processes
- filopodia
- cell membrane leading edge
- filopodial tip
- axons
- phagosomes
- cytolytic immune synapse
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vasp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- neural tube closure
- actin polymerization or depolymerization
- positive regulation of actin filament polymerization
- axon guidance
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- tight junction
- extracellular vesicular exosome
- focal adhesion
- actin cytoskeleton
- cytosol
- plasma membrane
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- SH3 domain binding
- profilin binding