Rraga Gene Summary [Mouse]
Enables GTP binding activity and GTPase activity. Involved in several processes, including glucose homeostasis; negative regulation of autophagy; and positive regulation of TOR signaling. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP; GATOR1 complex; and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human RRAGA (Ras related GTP binding A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rraga |
| Official Name | Ras-related GTP binding A [Source:MGI Symbol;Acc:MGI:1915691] |
| Ensembl ID | ENSMUSG00000070934 |
| Bio databases IDs | |
| Aliases | Ras-related GTP binding A |
| Synonyms | 1300010C19Rik, FIP-1, RAGA, Ras-related GTP binding A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rraga often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gtr1/RagA G protein conserved region
- ubiquitin protein ligase binding
- Ras family
- protein binding activity, bridging
- phosphoprotein binding
- GTPase
- leucine zipper domain
- coiled-coil domain
- enzyme
- protein binding
- GTP binding
- nucleotide-binding domain
- protein homodimerization
- Ras of Complex, Roc, domain of DAPkinase
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypoglycemia
- focal cortical dysplasia of Taylor
role in cell
- expression in
- differentiation
- phagocytosis by
- proliferation
- activation in
- migration
- quantity
- cellular infiltration by
- autophagy by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lysosome
- cytosol
- lysosome membrane
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rraga gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid starvation
- protein localization
- cellular response to starvation
- cellular response to amino acid stimulus
- tumor necrosis factor-mediated signaling pathway
- cellular response to nutrient levels
- negative regulation of autophagy
- glucose homeostasis
- apoptotic process
- protein localization in membrane
- positive regulation of TOR signaling cascade
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- lysosomal membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- protein binding
- protein heterodimerization activity
- GTPase activity
- protein anchor
- phosphoprotein binding