Gpr137b Gene Summary [Mouse]
Involved in negative regulation of bone resorption; negative regulation of osteoclast differentiation; and regulation of macrophage activation. Located in lysosomal membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr137b |
| Official Name | G protein-coupled receptor 137B [Source:MGI Symbol;Acc:MGI:1891463] |
| Ensembl ID | ENSMUSG00000021306 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 137B |
| Synonyms | C730041E01, D13Abb1e, G protein-coupled receptor 137B, TM7SF1, Transmembrane 7 superfamily member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr137b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr137b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- epithelial basal cell carcinoma
- Rett syndrome
- gastroesophageal reflux
role in cell
- activation in
- differentiation
- activation
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr137b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macrophage activation
- autophagy
- regulation of GTPase activity
- negative regulation of osteoclast differentiation
- regulation of autophagy
- negative regulation of bone resorption
Cellular Component
Where in the cell the gene product is active
- membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding