Shank2 Gene Summary [Mouse]
Enables ionotropic glutamate receptor binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and social behavior. Located in several cellular components, including dendritic spine; photoreceptor inner segment; and photoreceptor outer segment. Colocalizes with neurofilament and postsynaptic membrane. Is expressed in brain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shank2 |
| Official Name | SH3 and multiple ankyrin repeat domains 2 [Source:MGI Symbol;Acc:MGI:2671987] |
| Ensembl ID | ENSMUSG00000037541 |
| Bio databases IDs | |
| Aliases | SH3 and multiple ankyrin repeat domains 2 |
| Synonyms | AUTS17, CORTBP1, CTTNBP1, LOC103690160, M0R805, mKIAA1022, ProSAP1, SH3 and multiple ankyrin repeat domains 2, SHAN2, SHANK, Shank2E, SPANK-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shank2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- Ankyrin repeats (many copies)
- SAM (Sterile alpha motif )
- canonical PDZ domain
- Ankyrin repeats (3 copies)
- protein binding
- PDZ domain
- ionotropic glutamate receptor binding
- SH3-domain binding
- Ankyrin repeat
- Src Homology 3 domain superfamily
- Sterile alpha motif
- Ubl1_cv_Nsp3_N-like
- SAM domain (Sterile alpha motif)
- structural molecule
- N-terminal or F0 domain of Talin-head FERM
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Shank2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sarcoidosis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- hyperactive behavior
- neurodevelopmental disorder
- major depression
- susceptibility to autism type 17
- mental retardation
- pervasive developmental disorder
- purkinje cell degeneration
role in cell
- proliferation
- long term synaptic depression
- crizotinib sensitivity
- assembly
- abnormal morphology
- clustering
- long-term potentiation
- function in
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cilia
- cell periphery
- apical compartment
- cytosol
- membrane ruffles
- apical membrane
- postsynaptic membrane
- dendritic spines
- neurofilaments
- growth cone
- neurites
- synaptosomes
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- brush border
- perikaryon
- dendrites
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shank2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- negative regulation of hippo signaling cascade
- positive regulation of cell proliferation
- response to nutrient
- adult locomotory behavior
- response to xenobiotic stimulus
- learning
- associative learning
- synapse assembly
- long-term synaptic potentiation
- long term synaptic depression
- adult behavior
- vocalization behavior
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neuronal cell body
- neuron projection
- neurofilament
- plasma membrane
- photoreceptor outer segment
- growth cone
- brush border membrane
- presynaptic active zone
- postsynaptic membrane
- dendritic spine
- cytosol
- cilium membrane
- photoreceptor inner segment
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- protein binding
- GKAP/Homer scaffold activity
- SH3 domain binding