Ptrh2 Gene Summary [Mouse]
Predicted to enable peptidyl-tRNA hydrolase activity. Predicted to be involved in negative regulation of anoikis; negative regulation of gene expression; and positive regulation of anoikis. Located in mitochondrion. Is expressed in embryo. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptrh2 |
| Official Name | peptidyl-tRNA hydrolase 2 [Source:MGI Symbol;Acc:MGI:2444848] |
| Ensembl ID | ENSMUSG00000072582 |
| Bio databases IDs | |
| Aliases | peptidyl-tRNA hydrolase 2 |
| Synonyms | A230072I16Rik, BIT1, CFAP37, CGI-147, IMNEPD, peptidyl-tRNA hydrolase 2, PTH, PTH 2, RGD1306819 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptrh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidyl-tRNA hydrolase PTH2
- aminoacyl-tRNA hydrolase
- enzyme
- protein binding
- PTH2_family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dystrophy
- infantile-onset multisystem neurologic, endocrine, and pancreatic disease type 1
- runting
- progressive muscle weakness
- developmental delay
- centronuclear myopathy
- myopathy
- ataxia
- joint contracture
- infantile-onset multisystem neurologic, endocrine and pancreatic disease
regulates
- ERK
- TLE1
role in cell
- cell death
- apoptosis
- number
- abnormal morphology
- anoikis
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptrh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- negative regulation of anoikis
- apoptotic process
- positive regulation of anoikis
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- aminoacyl-tRNA hydrolase activity