Chst8 Gene Summary [Mouse]
Enables dermatan 4-sulfotransferase activity. Acts upstream of or within proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including foregut; genitourinary system; heart; nervous system; and pelvic girdle skeleton. Orthologous to human CHST8 (carbohydrate sulfotransferase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst8 |
| Official Name | carbohydrate sulfotransferase 8 [Source:MGI Symbol;Acc:MGI:1916197] |
| Ensembl ID | ENSMUSG00000060402 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 8 |
| Synonyms | 1500011J21Rik, carbohydrate sulfotransferase 8, carbohydrate sulphotransferase 8, GalNAc4ST, GALNAC4ST1, n acetylgalactosamine 4 o sulphotransferase, PSS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chst8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylgalactosamine-4-O-sulfotransferase
- enzyme
- protein binding
- Sulfotransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- psoriasis
- dental caries
- carcinoma in situ
- epithelial cancer in situ
- dyslexia
regulates
- testosterone
- LH
- sulfur-containing compound
- proteoglycan
- peptide hormone derivative
- chondroitin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chst8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- sulfur compound metabolic process
- carbohydrate biosynthetic process
- proteoglycan biosynthetic process
- hormone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- N-acetylgalactosamine 4-O-sulfotransferase activity
- sulfotransferase activity