Chrm3 Gene Summary [Mouse]
Enables G protein-coupled acetylcholine receptor activity. Involved in ligand-gated ion channel signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrm3 |
| Official Name | cholinergic receptor, muscarinic 3, cardiac [Source:MGI Symbol;Acc:MGI:88398] |
| Ensembl ID | ENSMUSG00000046159 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, muscarinic 3, cardiac |
| Synonyms | cholinergic receptor muscarinic 3, cholinergic receptor, muscarinic 3, cholinergic receptor, muscarinic 3, cardiac, EGBRS, HM3, LOC105373226, LOC107983951, M3, m3AChR, M3 mAChR, M3 MUSCARINIC receptor, M3R, M3 receptor, PBS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- signaling receptor activity
- binding protein
- cytoplasmic loop
- G-protein-coupled receptor binding
- transmembrane domain
- protein binding
- acetylcholine binding
Pathways
Biological processes and signaling networks where the Chrm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- urinary tract infection
- lung cancer
- prostate cancer
- breast cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- benign neoplasia
- iritis
role in cell
- apoptosis
- formation
- activation in
- cell death
- proliferation
- synthesis in
- growth
- phosphorylation in
- chemotaxis
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- synaptosomal membrane fractions
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- synaptic membrane
- basolateral membrane
- basal membrane
- synapse
- tight junctions
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- protein modification process
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- signal transduction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- nervous system development
- synaptic transmission
- G-protein coupled acetylcholine receptor signaling pathway
- positive regulation of smooth muscle contraction
- regulation of smooth muscle contraction
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- saliva secretion
- smooth muscle contraction
- positive regulation of insulin secretion
- calcium-mediated signaling
- regulation of ion transmembrane transporter activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- basal plasma membrane
- postsynaptic membrane
- synapse
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- signaling receptor activity
- acetylcholine binding
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity