Flnc Gene Summary [Mouse]
Predicted to enable ankyrin binding activity and identical protein binding activity. Involved in muscle cell development. Predicted to be located in several cellular components, including intercellular bridge; sarcolemma; and sarcoplasm. Is expressed in several structures, including diaphragm; embryo mesenchyme; heart; skeletal musculature; and spinal cord ventricular layer. Used to study myofibrillar myopathy 5. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Flnc |
| Official Name | filamin C, gamma [Source:MGI Symbol;Acc:MGI:95557] |
| Ensembl ID | ENSMUSG00000068699 |
| Bio databases IDs | |
| Aliases | filamin C, gamma |
| Synonyms | 1110055E19RIK, ABP-280, ABP280A, ABPA, ABP-L, ARVC15, CMH26, filamin C, filamin C, gamma, filamin C, γ, Filamin gamma, Filamin γ, FLN2, gamma FILAMIN, MFM5, MPD4, RCM5, γ FILAMIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flnc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Filamin/ABP280 repeat
- Calponin homology domain
- immunoglobulin domain
- protein binding
- identical protein binding
- actin-binding domain
- cytoskeletal protein binding
- ankyrin binding
- actin binding
- calponin homology (CH) domain superfamily
- hinge domain
- immunoglobulin-like protein domain
- Filamin-type immunoglobulin domains
Pathways
Biological processes and signaling networks where the Flnc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- centronuclear myopathy
- filamin C-related myofibrillar myopathy
- endometrial cancer
- primary dilated cardiomyopathy
- distal myopathy type 4
- cardiomyopathy
- familial hypertrophic cardiomyopathy 26
- familial primary dilated cardiomyopathy
- cardiovascular disorder
phenotypes
- abnormal blood vessel morphology
- abnormal embryo size
- abnormal forebrain development
- abnormal heart looping
- abnormal heart morphology
- abnormal pericardium morphology
- abnormal placenta size
- abnormal somite shape
- abnormal vitelline vasculature morphology
- embryonic lethality prior to tooth bud stage
- preweaning lethality complete penetrance
- abnormal Z line morphology
- abnormal diaphragm morphology
- abnormal extensor digitorum longus morphology
- abnormal intercostal muscle morphology
- abnormal muscle fiber morphology
- abnormal myogenesis
- abnormal sarcomere morphology
- abnormal skeletal muscle fiber morphology
- abnormal skeletal muscle morphology
- abnormal soleus morphology
- abnormal tibialis anterior morphology
- centrally nucleated skeletal muscle fibers
- decreased fetal size
- decreased food intake
- decreased grip strength
- decreased respiratory quotient
- decreased skeletal muscle fiber number
- decreased skeletal muscle mass
- decreased vertical activity
- hypoactivity
- hyporesponsive to tactile stimuli
- increased variability of skeletal muscle fiber size
- neonatal lethality complete penetrance
- respiratory failure
- skeletal muscle fiber degeneration
role in cell
- morphology
- activation in
- quantity
- differentiation
- organization
- fusion
- number
- migration
- reorganization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- sarcoplasmic reticulum
- myofilaments
- costameres
- cytoplasmic bridges
- cytosol
- sarcoplasm
- sarcolemma
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flnc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcomere organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- intercellular bridge
- cytoskeleton
- focal adhesion
- sarcoplasm
- cytoplasm
- sarcolemma
- costamere
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- ankyrin binding
- cytoskeletal protein binding