Nme3 Gene Summary [Mouse]
Enables nucleoside diphosphate kinase activity. Predicted to be involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Located in ciliary basal body. Is expressed in several structures, including gut; hemolymphoid system gland; nervous system; respiratory system; and sensory organ. Orthologous to human NME3 (NME/NM23 nucleoside diphosphate kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nme3 |
| Official Name | NME/NM23 nucleoside diphosphate kinase 3 [Source:MGI Symbol;Acc:MGI:1930182] |
| Ensembl ID | ENSMUSG00000073435 |
| Bio databases IDs | |
| Aliases | NME/NM23 nucleoside diphosphate kinase 3 |
| Synonyms | 1810009F08Rik, c371H6.2, DR-nm23, Ndk3, NDPK-C, Nm23-DR, NM23-H3, Nm23-M3, NME/NM23 nucleoside diphosphate kinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nme3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- Nucleoside diphosphate kinase family
- NDPk
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- cell viability
- differentiation
- adhesion
- cytostasis
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nme3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- UTP biosynthetic process
- CTP biosynthetic process
- GTP biosynthetic process
- mitochondrial fusion
- nucleoside triphosphate biosynthetic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium basal body
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- nucleoside diphosphate kinase activity