Ehd2 Gene Summary [Mouse]
Enables identical protein binding activity and protein domain specific binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of endocytic recycling; and positive regulation of myoblast fusion. Acts upstream of or within cortical actin cytoskeleton organization and endocytosis. Located in caveola; cytosol; and perinuclear region of cytoplasm. Is expressed in several structures, including brown fat; neural tube; and vascular element. Orthologous to human EHD2 (EH domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ehd2 |
| Official Name | EH-domain containing 2 [Source:MGI Symbol;Acc:MGI:2154274] |
| Ensembl ID | ENSMUSG00000074364 |
| Bio databases IDs | |
| Aliases | EH-domain containing 2 |
| Synonyms | C130052H20Rik, EH-domain containing 2, MGEPS, PAST2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ehd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF5600)
- nucleic acid binding
- 50S ribosome-binding GTPase
- EFh
- protein domain specific binding
- Eps15 homology domain
- protein binding
- identical protein binding
- N-terminal EH-domain containing protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- Cytoskeletal-regulatory complex EF hand
- Dynamin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- chronic sinusitis
- obesity
- renal clear cell adenocarcinoma
- renal clear cell cancer
- liver neoplasia
- digestive system cancer
role in cell
- size
- expression in
- growth
- phosphorylation in
- molecular cleavage in
- number
- ruffling
- organization
- reassembly
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- microtubule cytoskeleton
- perinuclear region
- cellular membrane
- Plasma Membrane
- cytoplasmic bridges
- lipid droplets
- cytosol
- caveolae
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ehd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- cortical actin cytoskeleton organization
- cilium morphogenesis
- positive regulation of endocytic recycling
- endocytosis
- protein localization in plasma membrane
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- plasma membrane
- endocytic vesicle
- nucleus
- intercellular bridge
- caveola
- early endosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- endosome membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- GTP binding
- ATP binding
- protein domain specific binding
- identical protein binding
- protein binding
- calcium ion binding
- hydrolase activity