Eif2s2 Gene Summary [Mouse]
Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Acts upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Is active in synapse. Is expressed in several structures, including blastocyst; colon; early embryo; gonad; and liver. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif2s2 |
| Official Name | eukaryotic translation initiation factor 2, subunit 2 (beta) [Source:MGI Symbol;Acc:MGI:1914454] |
| Ensembl ID | ENSMUSG00000074656 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2, subunit 2 (beta) |
| Synonyms | 2810026E11Rik, D2Ertd303e, EIF2, EIF2B, eIF-2-beta, eIF-2-β, eukaryotic translation initiation factor 2 subunit 2 beta, eukaryotic translation initiation factor 2 subunit 2 β, eukaryotic translation initiation factor 2 subunit beta, eukaryotic translation initiation factor 2 subunit β, PPP1R67 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif2s2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in IF2B/IF5
- nucleic acid binding translation factor
- lysine rich domain
- translation initiation factor
- protein binding
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the Eif2s2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- luminal breast cancer
- psoriasis
- androgenic alopecia
role in cell
- cell death
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosomal fraction
- ribosome
- Nucleus
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif2s2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation preinitiation complex
- male gonad development
- in utero embryonic development
- cytoplasmic translational initiation
- male germ cell proliferation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
- eukaryotic translation initiation factor 2 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding
- metal ion binding
- mRNA binding
- translation factor activity, nucleic acid binding
- translation initiation factor binding