Foxs1 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in blood vessel development; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular process controlling balance and regulation of growth. Located in nucleus. Is expressed in several structures, including ganglia; genitourinary system; gut; hemolymphoid system gland; and yolk sac. Orthologous to human FOXS1 (forkhead box S1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxs1 |
| Official Name | forkhead box S1 [Source:MGI Symbol;Acc:MGI:95546] |
| Ensembl ID | ENSMUSG00000074676 |
| Bio databases IDs | |
| Aliases | forkhead box S1 |
| Synonyms | FKH3, FKHL18, forkhead box S1, FREAC10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FH_FOX
- nucleic acid binding
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- metastasis
- colorectal cancer
- organismal death
- preeclampsia
- atherosclerosis
- medulloblastoma SHH subtype
- brain cancer
- carbon tetrachloride-induced liver fibrosis
role in cell
- expression in
- apoptosis
- phosphorylation in
- proliferation
- growth
- migration
- invasion by
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- blood vessel development
- negative regulation of transcription, DNA-dependent
- cell differentiation
- negative regulation of sequence-specific DNA binding transcription factor activity
- anatomical structure morphogenesis
- neuromuscular process controlling balance
- positive regulation of multicellular organism growth
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity