Cerkl Gene Summary [Mouse]
Enables sphingolipid binding activity. Acts upstream of or within sphingolipid biosynthetic process. Located in several cellular components, including perinuclear region of cytoplasm; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in eye and optic nerve. Used to study retinitis pigmentosa 26. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 26. Orthologous to human CERKL (CERK like autophagy regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cerkl |
| Official Name | ceramide kinase-like [Source:MGI Symbol;Acc:MGI:3037816] |
| Ensembl ID | ENSMUSG00000075256 |
| Bio databases IDs | |
| Aliases | ceramide kinase-like |
| Synonyms | ceramide kinase-like, CERK like autophagy regulator, Gm1958, RGD1561057, RP26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cerkl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ceramide kinase C-terminal domain
- sphingolipid binding
- Diacylglycerol kinase catalytic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 26
- fundus flavimaculatus
- retinitis pigmentosa
- retinal dystrophy
- autosomal recessive retinitis pigmentosa
- cone-rod dystrophy
- COVID-19
- covid-19 death
- macular degeneration
- peptic ulcer disease
regulates
- glutathione
- reactive oxygen species
- sphingolipid
role in cell
- apoptosis
- number
- ferroptosis
- shape change
- mitochondrial respiration in
- shape change in
- necroptosis
- shortening in
- shortening
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- photoreceptor outer segments
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cerkl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphorylation
- sphingolipid biosynthetic process
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- nucleolus
- photoreceptor inner segment
- photoreceptor outer segment
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- lipid kinase activity
- sphingolipid binding