Eif3i Gene Summary [Mouse]
Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including extracellular matrix; jaw; oral epithelium; and skeleton. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif3i |
| Official Name | eukaryotic translation initiation factor 3, subunit I [Source:MGI Symbol;Acc:MGI:1860763] |
| Ensembl ID | ENSMUSG00000028798 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3, subunit I |
| Synonyms | D4Ertd632e, eIF3-beta, eIF3-p36, EIF3S2, eIF3-β, eukaryotic translation initiation factor 3 subunit I, eukaryotic translation initiation factor 3, subunit I, PRO2242, TGF-β receptor binding, Tif3, TRIP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif3i often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- translation initiation factor
- WD40
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the Eif3i gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- colon cancer
- organismal death
- colorectal cancer
- infection by vesicular stomatitis virus
role in cell
- expression in
- synthesis in
- proliferation
- cell cycle progression
- phosphorylation in
- apoptosis
- growth
- migration
- colony formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- intracellular space
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif3i gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- cytoplasmic translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- eukaryotic translation initiation factor 3 complex, eIF3m
- eukaryotic 43S preinitiation complex
- cytosol
- synapse
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding