Mical3 Gene Summary [Mouse]
Predicted to enable several functions, including FAD binding activity; actin binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in actin filament depolymerization. Predicted to be located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. Is expressed in several structures, including axial skeleton; central nervous system; hindlimb interdigital region mesenchyme; sensory organ; and vibrissa. Orthologous to human MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mical3 |
| Official Name | microtubule associated monooxygenase, calponin and LIM domain containing 3 [Source:MGI Symbol;Acc:MGI:2442733] |
| Ensembl ID | ENSMUSG00000051586 |
| Bio databases IDs | |
| Aliases | microtubule associated monooxygenase, calponin and LIM domain containing 3 |
| Synonyms | BC030863, C130040D16Rik, KIAA0819, KIAA1364, LOC100504032, LOC100505050, LOC685601, LOC729269, microtubule associated monooxygenase, calponin and LIM domain containing 3, mKIAA1364, RGD1306314 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mical3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- Calponin homology domain
- MAPK-interacting and spindle-stabilising protein-like
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actin binding
- Bivalent Mical/EHBP Rab binding domain
- NAD(P)-binding Rossmann-like domain
- calponin homology (CH) domain superfamily
- enzyme
- protein binding
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- pancreatic carcinoma
- chronic obstructive pulmonary disease
- coronary artery disease
- pancreatic epithelial cancer
- nonalcoholic fatty liver disease
- infection by HIV-1
role in cell
- sphere formation
- organization
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Flemming body
- cytoplasmic bridges
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mical3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cytoskeleton organization
- actin filament depolymerization
- exocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- cell cortex
- spindle
- cytosol
- cell projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FAD binding
- actin binding
- metal ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
- binding, bridging