Cdh17 Gene Summary [Mouse]
Enables proton-dependent oligopeptide secondary active transmembrane transporter activity. Involved in germinal center B cell differentiation; marginal zone B cell differentiation; and spleen development. Acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and oligopeptide transport. Located in cell surface and plasma membrane. Is expressed in several structures, including common bile duct; genitourinary system; gut; spleen; and trunk. Orthologous to human CDH17 (cadherin 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh17 |
| Official Name | cadherin 17 [Source:MGI Symbol;Acc:MGI:1095414] |
| Ensembl ID | ENSMUSG00000028217 |
| Bio databases IDs | |
| Aliases | cadherin 17 |
| Synonyms | cadherin 17, CDH16, HPT-1, HPT-1/LI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ectodomain
- integrin binding
- RGD motif
- Cadherin repeat-like domain
- protein binding
- proton-dependent oligopeptide transporter
- transporter
Pathways
Biological processes and signaling networks where the Cdh17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial neoplasia
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- colorectal cancer
- organismal death
role in cell
- phosphorylation in
- proliferation
- activation in
- adhesion
- number
- differentiation
- cell proliferation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cell surface
- cellular membrane
- basolateral membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligopeptide transmembrane transport
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- adherens junction organization
- multicellular organismal development
- cell morphogenesis
- spleen development
- cell adhesion
- homophilic cell adhesion
- oligopeptide transport
- germinal center B cell differentiation
- integrin-mediated signaling pathway
- positive regulation of integrin activation by cell surface receptor linked signal transduction
- marginal zone B cell differentiation
- cell-cell adhesion mediated by cadherin
- cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell junction
- catenin complex
- basolateral plasma membrane
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-dependent oligopeptide secondary active transmembrane transporter activity
- cadherin binding
- calcium ion binding
- integrin binding
- beta-catenin binding