Foxd1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance and branching involved in ureteric bud morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxd1 |
| Official Name | forkhead box D1 [Source:MGI Symbol;Acc:MGI:1347463] |
| Ensembl ID | ENSMUSG00000078302 |
| Bio databases IDs | |
| Aliases | forkhead box D1 |
| Synonyms | BF-2, FKHL8, Forkhead box d1, FREAC-4, Hfh10, Hfhbf2, LOC684320 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- DNA binding domain
- nucleic acid binding
- DNA bending protein
- sequence-specific DNA binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- pancreatic cancer
- metastasis
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- breast cancer
- bronchopulmonary dysplasia
- uterine serous papillary cancer
role in cell
- expression in
- proliferation
- migration
- glycolysis in
- guidance
- invasion by
- transactivation in
- activation
- hyperactivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- luteinizing hormone secretion
- axon guidance
- anatomical structure morphogenesis
- positive regulation of kidney development
- positive regulation of transcription from RNA polymerase II promoter
- dichotomous subdivision of terminal units involved in ureteric bud branching
- regulation of transcription from RNA polymerase II promoter
- positive regulation of BMP signaling pathway
- nephrogenic mesenchyme development
- negative regulation of transcription, DNA-dependent
- metanephric capsule development
- metanephric capsule specification
- positive regulation of gene expression
- metanephric nephron development
- cell differentiation
- canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- DNA binding, bending
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity