Dact3 Gene Summary [Mouse]
Enables several functions, including delta-catenin binding activity; identical protein binding activity; and protein kinase C binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and negative regulation of epithelial to mesenchymal transition. Located in cytoplasm. Is expressed in several structures, including branchial arch artery; central nervous system; embryo mesenchyme; genitourinary system; and tooth. Orthologous to human DACT3 (dishevelled binding antagonist of beta catenin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dact3 |
| Official Name | dishevelled-binding antagonist of beta-catenin 3 [Source:MGI Symbol;Acc:MGI:3654828] |
| Ensembl ID | ENSMUSG00000078794 |
| Bio databases IDs | |
| Aliases | dishevelled-binding antagonist of beta-catenin 3 |
| Synonyms | DAPPER3, dishevelled-binding antagonist of beta-catenin 3, dishevelled-binding antagonist of β-catenin 3, EG666671, MGC15476, naa-3, RGD1563892, RRR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dact3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- Dapper
- protein kinase C binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- androgenic alopecia
- tubulo-interstitial fibrosis
- endometrial cancer
- growth failure
- colorectal adenoma
- colorectal adenoma formation
role in cell
- growth
- expression in
- activation
- accumulation in
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dact3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of epithelial to mesenchymal transition
- negative regulation of cell growth
- canonical Wnt receptor signaling pathway
- epithelial to mesenchymal transition
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- delta-catenin binding
- identical protein binding
- protein kinase A binding