Bloc1s1 Gene Summary [Mouse]
Predicted to enable protein-lysine-acetyltransferase activity. Involved in anterograde synaptic vesicle transport. Located in cytosol; early endosome; and mitochondrion. Part of BLOC-1 complex. Is expressed in brain; long bone epiphyseal plate hypertrophic zone; and long bone epiphyseal plate proliferative zone. Orthologous to human BLOC1S1 (biogenesis of lysosomal organelles complex 1 subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bloc1s1 |
| Official Name | biogenesis of lysosomal organelles complex-1, subunit 1 [Source:MGI Symbol;Acc:MGI:1195276] |
| Ensembl ID | ENSMUSG00000090247 |
| Bio databases IDs | |
| Aliases | biogenesis of lysosomal organelles complex-1, subunit 1 |
| Synonyms | biogenesis of lysosomal organelles complex 1 subunit 1, biogenesis of lysosomal organelles complex-1, subunit 1, BLOC-1 subunit 1, BLOS1, BORCS1, GCN5L1, GCN5-like protein 1, MICoA, RT14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bloc1s1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyltransferase
- GCN5-like protein 1 (GCN5L1)
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- nonalcoholic steatohepatitis
role in cell
- fragmentation in
- production in
- phosphorylation in
- expression in
- degradation in
- accumulation in
- acetylation in
- formation
- migration
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- lysosome membrane
- early endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bloc1s1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- platelet dense granule organization
- organelle transport along microtubule
- melanosome organization
- regulation of endosome size
- peptidyl-lysine acetylation
- anterograde axon cargo transport
- neuron projection development
- endosomal transport
- aerobic respiration
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- BLOC-1 complex
- early endosome
- mitochondrial intermembrane space
- extracellular space
- mitochondrial matrix
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding