Flii Gene Summary [Mouse]
This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Details
| Type | Retained Intron |
| Official Symbol | Flii |
| Official Name | flightless I actin binding protein [Source:MGI Symbol;Acc:MGI:1342286] |
| Ensembl ID | ENSMUSG00000002812 |
| Bio databases IDs | |
| Aliases | flightless I actin binding protein |
| Synonyms | 3632430F08Rik, CMD2J, FLI, Fli1, flightless I actin binding protein, FLII actin remodeling protein, FLII, actin remodeling protein, FLIIH, FLIL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flii often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- leucine rich domain
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Gelsolin repeat
- DNA binding domain
- actin binding
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary dilated cardiomyopathy
- dilated cardiomyopathy type 2J
- cardiomyopathy
- serous ovarian adenocarcinoma
- serous ovarian cancer
- infection by HIV-1
role in cell
- expression in
- proliferation
- survival
- activation in
- organization
- shortening
- severing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane/cytoplasmic fraction
- Cytoplasm
- perinuclear region
- podosomes
- actin cytoskeleton
- centrosome
- cytosol
- nucleoplasm
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flii gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- barbed-end actin filament capping
- actin filament severing
- actin polymerization or depolymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- brush border
- focal adhesion
- cytoplasm
- centriolar satellite
- actin cytoskeleton
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- actin binding