Manf Gene Summary [Mouse]
Predicted to enable sulfatide binding activity. Acts upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Predicted to be located in endoplasmic reticulum lumen; extracellular space; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; hemolymphoid system gland; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Manf |
| Official Name | mesencephalic astrocyte-derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:1922090] |
| Ensembl ID | ENSMUSG00000032575 |
| Bio databases IDs | |
| Aliases | mesencephalic astrocyte-derived neurotrophic factor |
| Synonyms | 3230402M22Rik, AA673178, ARGININE-RICH, ARMET, ARP, D18Mgi17, DDDS, mesencephalic astrocyte-derived neurotrophic factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Manf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ARMET, C-terminal
- lipid binding
- binding protein
- protein binding
- ARMET, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- pancreatic cancer
- non-insulin-dependent diabetes mellitus
- obesity
- disrupted blood brain barrier
- idiopathic habitual abortion
- hepatic steatosis
- diabetes, deafness, developmental delay, and short stature syndrome
- hepatic necrosis
- renal impairment
role in cell
- expression in
- proliferation
- quantity
- phosphorylation in
- apoptosis
- migration
- cell viability
- cell death
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- perinuclear region
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Manf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopaminergic neuron differentiation
- signal transduction
- neuron projection development
- response to unfolded protein
- vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- extracellular space
- cytosol
- endoplasmic reticulum
- extracellular region
- sarcoplasmic reticulum lumen
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- RNA binding
- protein binding