Dek Gene Summary [Mouse]
Predicted to enable histone binding activity. Acts upstream of or within regulation of double-strand break repair via nonhomologous end joining. Located in contractile muscle fiber and nucleus. Is expressed in several structures, including early conceptus; limb; oocyte; retina; and telencephalon. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dek |
| Official Name | DEK proto-oncogene (DNA binding) [Source:MGI Symbol;Acc:MGI:1926209] |
| Ensembl ID | ENSMUSG00000021377 |
| Bio databases IDs | |
| Aliases | DEK proto-oncogene (DNA binding) |
| Synonyms | 1810019E15Rik, D13H6S231E, D6S231E, DEK proto-oncogene |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dek often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- SAP motif
- SAP domain
- DEK C terminal domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- prostate cancer
- myelomonocytic leukemia
- lung cancer
- cancer
- melanoma
- melanoma cancer
- renal cancer
- colon cancer
- juvenile rheumatoid arthritis
role in cell
- cell death
- expression in
- apoptosis
- proliferation
- quantity
- progression
- differentiation
- chemoattraction
- protection
- progression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasmic fraction
- Cytoplasm
- vesicles
- nucleoplasm
- nucleoli
- myofibrils
- exosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dek gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of double-strand break repair via nonhomologous end joining
- chromatin remodeling
- regulation of double-strand break repair
- signal transduction
- viral genome replication
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- contractile fiber
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- histone binding