Kctd12 Gene Summary [Mouse]
Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Part of receptor complex. Is active in GABA-ergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and inner ear. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kctd12 |
| Official Name | potassium channel tetramerisation domain containing 12 [Source:MGI Symbol;Acc:MGI:2145823] |
| Ensembl ID | ENSMUSG00000098557 |
| Bio databases IDs | |
| Aliases | potassium channel tetramerisation domain containing 12 |
| Synonyms | AU046135, AW538430, C13orf2, Kctd12 predicted, LOC115207, PFET1, PFETIN, potassium channel tetramerisation domain containing 12, POTASSIUM CHANNEL TETRAMERIZATION domain containing 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kctd12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- H1 domain found in potassium channel tetramerization domain-containing proteins
- neurotransmitter receptor
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding
- identical protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma formation
- epithelial cancer
- lung cancer
- lung adenocarcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- pancreatic epithelial cancer
- hepatocellular carcinoma
- head and neck squamous cell cancer
role in cell
- activation in
- proliferation
- quantity
- phosphorylation in
- action potential
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic membrane
- postsynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kctd12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homooligomerization
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic membrane
- receptor complex
- cell projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding