Pfkfb1 Gene Summary [Rat]
Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including carbohydrate phosphorylation; positive regulation of phosphate metabolic process; and response to glucagon. Part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Biomarker of hyperinsulinism. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfkfb1 |
| Official Name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [Source:RGD Symbol;Acc:3307] |
| Ensembl ID | ENSRNOG00000000165 |
| Bio databases IDs | |
| Aliases | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
| Synonyms | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, 6-phosphofructo-2-kinase f-type, F6PK, HL2K, PFK2, Pfkfb01, PFK/FBPase 1, PFRX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pfkfb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- bisphosphatase domain
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- fructose-2,6-bisphosphate 2-phosphatase
- ATP binding
- enzyme
- protein binding
- identical protein binding
- AAA domain
- kinase domain
- kinase binding
- binding protein
- NK
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- Pka phosphorylation site
- 6-phosphofructo-2-kinase
Pathways
Biological processes and signaling networks where the Pfkfb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- Huntington disease
- fibrosis
- pulmonary congestion
regulates
- D-glucose
- GCK
- G6PC1
- triacylglycerol
- fructose-2,6-bisphosphate
- AKT
- lactic acid
- UDP-N-acetylglucosamine
- fructose-6-phosphate
- fatty acid
role in cell
- cell death
- glycolysis in
- gluconeogenesis in
- contractility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pfkfb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- response to insulin stimulus
- glycolysis
- response to glucocorticoid stimulus
- response to starvation
- fructose 2,6-bisphosphate metabolic process
- response to cAMP
- response to glucagon stimulus
- fructose metabolic process
- organ regeneration
- carbohydrate phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- fructose-6-phosphate binding
- fructose-2,6-bisphosphate 2-phosphatase activity
- kinase binding
- 6-phosphofructo-2-kinase activity