Pbld1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and isomerase activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to act upstream of or within with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm. Orthologous to human PBLD (phenazine biosynthesis like protein domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pbld1 |
| Official Name | phenazine biosynthesis-like protein domain containing 1 [Source:RGD Symbol;Acc:621263] |
| Ensembl ID | ENSRNOG00000000386 |
| Bio databases IDs | |
| Aliases | phenazine biosynthesis-like protein domain containing 1 |
| Synonyms | HEL-S-306, MAWBP, MAWDBP, Pbld1, phenazine biosynthesis like protein domain containing, phenazine biosynthesis-like protein domain containing 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pbld1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YHI9
- enzyme
- protein binding
- Phenazine biosynthesis-like protein
- phenazine biosynthesis protein PhzF family
- identical protein binding
- diaminopimelate epimerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- epithelial cancer
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
- Parkinson disease
- autoimmune pancreatitis
- mixed connective tissue disease
- colorectal adenoma
- colorectal adenoma formation
- ulcerative colitis
role in cell
- expression in
- activation in
- growth
- epithelial barrier function
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pbld1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of gastrointestinal epithelium
- biosynthetic process
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- isomerase activity