PBLD Gene Summary [Human]
Enables identical protein binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of SMAD protein signal transduction; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PBLD |
| Official Name | phenazine biosynthesis like protein domain containing [Source:HGNC Symbol;Acc:HGNC:23301] |
| Ensembl ID | ENSG00000108187 |
| Bio databases IDs | |
| Aliases | phenazine biosynthesis like protein domain containing |
| Synonyms | HEL-S-306, MAWBP, MAWDBP, Pbld1, phenazine biosynthesis like protein domain containing, phenazine biosynthesis-like protein domain containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PBLD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YHI9
- enzyme
- protein binding
- Phenazine biosynthesis-like protein
- phenazine biosynthesis protein PhzF family
- identical protein binding
- diaminopimelate epimerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- epithelial cancer
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
- Parkinson disease
- autoimmune pancreatitis
- mixed connective tissue disease
- colorectal adenoma
- colorectal adenoma formation
- ulcerative colitis
role in cell
- expression in
- activation in
- growth
- epithelial barrier function
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PBLD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of gastrointestinal epithelium
- biosynthetic process
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- isomerase activity