Ccn6 Gene Summary [Rat]
Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of cell differentiation; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in arthropathy and progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccn6 |
| Official Name | cellular communication network factor 6 [Source:RGD Symbol;Acc:1564120] |
| Ensembl ID | ENSRNOG00000000597 |
| Bio databases IDs | |
| Aliases | cellular communication network factor 6 |
| Synonyms | cellular communication network factor 6, Gm735, LIBC, PPAC, PPD, PPRD, RGD1564120, WISP-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccn6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- Thrombospondin type 1 domain
- Spondin-like TSP1 domain
- Insulin-like growth factor binding protein
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- progressive pseudorheumatoid dysplasia
- breast carcinoma
- hereditary disorder
- tumorigenesis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- ovarian cancer
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- cell viability
- binding in
- proliferation
- growth
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccn6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- regulation of mitochondrial membrane potential
- signal transduction
- negative regulation of cell proliferation
- cell-cell signaling
- positive regulation of cell differentiation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrion
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- integrin binding
- heparin binding