Wnt4 Gene Summary [Rat]
Predicted to enable cytokine activity; frizzled binding activity; and transcription corepressor activity. Involved in cellular response to estradiol stimulus; response to benzoic acid; and response to retinoic acid. Predicted to be located in cell surface; cytoplasm; and extracellular matrix. Predicted to be active in extracellular space. Used to study acute kidney failure. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt4 |
| Official Name | Wnt family member 4 [Source:RGD Symbol;Acc:621348] |
| Ensembl ID | ENSRNOG00000013166 |
| Bio databases IDs | |
| Aliases | Wnt family member 4 |
| Synonyms | SERKAL, wingless-type MMTV integration site family, member 4, Wnt family member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- wnt family
- receptor agonist activity
- protein binding
- receptor binding
- cytokine
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- obesity
- uterine prolapse
- androgenic alopecia
- endometriosis
- Müllerian aplasia and hyperandrogenism
- developmental delay
- squamous metaplasia
- carpal tunnel syndrome
role in cell
- activity
- expression in
- accumulation in
- quantity
- apoptosis
- activation in
- phosphorylation in
- invasion by
- proliferation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- endocytic vesicle membrane
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- Plasma Membrane
- Golgi Apparatus
- endoplasmic reticulum lumen
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- male gonad development
- regulation of cell-cell adhesion
- thyroid-stimulating hormone-secreting cell differentiation
- Sertoli cell differentiation
- fibroblast growth factor receptor signaling pathway
- female gonad development
- somatotropin secreting cell differentiation
- positive regulation of collagen biosynthetic process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- kidney development
- mammary gland epithelium development
- positive regulation of bone mineralization
- negative regulation of steroid biosynthetic process
- mesenchymal to epithelial transition
- negative regulation of wound healing
- neuron differentiation
- negative regulation of testicular blood vessel morphogenesis
- paramesonephric duct development
- cellular response to transforming growth factor beta stimulus
- negative regulation of gene expression
- metanephric tubule formation
- positive regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- epithelial to mesenchymal transition
- embryonic epithelial tube formation
- negative regulation of cell migration
- negative regulation of androgen biosynthetic process
- apoptotic signaling pathway
- tertiary branching involved in mammary gland duct morphogenesis
- positive regulation of osteoblast differentiation
- immature T cell proliferation in thymus
- smooth muscle cell differentiation
- negative regulation of male gonad development
- metanephric mesenchymal cell differentiation
- negative regulation of cell differentiation
- liver development
- canonical Wnt receptor signaling pathway
- positive regulation of aldosterone biosynthetic process
- adrenal gland development
- positive regulation of meiosis
- positive regulation of dermatome development
- cellular response to starvation
- positive regulation of MAPK cascade
- hormone metabolic process
- renal vesicle formation
- metanephric nephron morphogenesis
- oocyte development
- branching involved in ureteric bud morphogenesis
- cell fate commitment
- renal vesicle induction
- positive regulation of cortisol biosynthetic process
- female sex determination
- non-canonical Wnt receptor signaling pathway
- negative regulation of testosterone biosynthetic process
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- extracellular matrix
- Golgi lumen
- extracellular region
- plasma membrane
- endocytic vesicle membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- transcription corepressor activity
- receptor agonist activity
- cytokine activity