Wnt16 Gene Summary [Rat]
Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in several processes, including keratinocyte proliferation; oxidative stress-induced premature senescence; and regulation of signal transduction. Predicted to act upstream of or within bone remodeling and cardiac epithelial to mesenchymal transition. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human WNT16 (Wnt family member 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt16 |
| Official Name | Wnt family member 16 [Source:RGD Symbol;Acc:1562253] |
| Ensembl ID | ENSRNOG00000005781 |
| Bio databases IDs | |
| Aliases | Wnt family member 16 |
| Synonyms | E130309I19Rik, wingless-type MMTV integration site family, member 16, Wnt family member 16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- androgenic alopecia
- ischemic cardiomyopathy
- skin basal cell carcinoma
- basal cell skin cancer
- mantle cell lymphoma
role in cell
- apoptosis
- expression in
- binding in
- proliferation
- activation in
- differentiation
- morphology
- replicative senescence
- accumulation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxidative stress-induced premature senescence
- keratinocyte proliferation
- bone remodeling
- replicative senescence
- neuron differentiation
- cardiac epithelial to mesenchymal transition
- keratinocyte differentiation
- positive regulation of JNK cascade
- positive regulation of gene expression
- cell fate commitment
- optic cup formation involved in camera-type eye development
- Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- negative regulation of apoptotic signaling pathway
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- cytokine activity