Pla2g1b Gene Summary [Rat]
Enables calcium-dependent phospholipase A2 activity and signaling receptor binding activity. Involved in fatty acid biosynthetic process; phospholipid metabolic process; and positive regulation of cell population proliferation. Located in cell surface and secretory granule. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g1b |
| Official Name | phospholipase A2 group IB [Source:RGD Symbol;Acc:61949] |
| Ensembl ID | ENSRNOG00000001153 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IB |
| Synonyms | phospholipase A2 group IB, phospholipase A2, group IB, pancreas, PLA2, PLA2A, PLA2 GROUP 1B, PPLA2, sPLA2IB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- calcium-dependent phospholipase A2
- calcium ion binding
- enzyme
- receptor binding
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- lung adenocarcinoma
- lung adenocarcinoma formation
- hyperlipidemia
- morbid obesity
- idiopathic membranous nephropathy
regulates
- arachidonic acid
- D-glucose
- AKT
- Ca2+
- CXCL8
- MMP2
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- lipid
role in cell
- phosphorylation in
- proliferation
- chemotaxis
- migration
- autophagy in
- organization
- transport in
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cell surface
- granules
- cytosol
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of cell proliferation
- actin filament organization
- phospholipid metabolic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- cellular response to insulin stimulus
- positive regulation of fibroblast proliferation
- positive regulation of protein secretion
- positive regulation of immune response
- defense response to Gram-positive bacterium
- intracellular signal transduction
- signal transduction
- regulation of glucose import
- fatty acid biosynthetic process
- phosphatidylglycerol metabolic process
- positive regulation of interleukin-8 production
- neutrophil mediated immunity
- phosphatidylcholine metabolic process
- leukotriene biosynthetic process
- innate immune response in mucosa
- arachidonic acid secretion
- lipid catabolic process
- neutrophil chemotaxis
- antibacterial humoral response
- activation of phospholipase A2 activity
- positive regulation of calcium ion transport into cytosol
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- bile acid binding
- phospholipid binding
- receptor binding