Pla2g2a Gene Summary [Rat]
Enables calcium-dependent phospholipase A2 activity. Involved in phospholipid metabolic process. Located in perinuclear region of cytoplasm and secretory granule. Human ortholog(s) of this gene implicated in cholecystolithiasis; colorectal cancer; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Orthologous to human PLA2G2A (phospholipase A2 group IIA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g2a |
| Official Name | phospholipase A2 group IIA [Source:RGD Symbol;Acc:620857] |
| Ensembl ID | ENSRNOG00000016945 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IIA |
| Synonyms | 14-3-3, EF, GIIC sPLA2, MOM1, phospholipase A2 group IIA, phospholipase A2, group IIA (platelets, synovial fluid), PHOSPHOLIPASE A2 type IIA, PLA2, PLA2B, PLA2L, PLA2S, Pla2 type IIA, PLAS1, RASF-A, sPLA2, sPLA2-IIA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- calcium-dependent phospholipase A2
- enzyme
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- adenoma formation
- benign neoplasia
- infection
- Alzheimer disease
- primary oral squamous cell carcinoma
- tendonitis
- ankylosing spondylitis
- cardiac fibrosis
role in cell
- cell death
- expression in
- growth
- survival
- proliferation
- differentiation
- activation
- killing
- organismal death
- lysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- membrane fraction
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- caveolae
- mitoplasts
- secretory granules
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle remodeling
- positive regulation of inflammatory response
- phosphatidylethanolamine metabolic process
- phospholipid metabolic process
- inflammatory response
- phosphatidylcholine metabolic process
- arachidonic acid secretion
- negative regulation of T cell proliferation
- phosphatidic acid metabolic process
- lipid catabolic process
- positive regulation of ERK1 and ERK2 cascade
- killing of cells of other organism
- positive regulation of macrophage derived foam cell differentiation
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- secretory granule
- endoplasmic reticulum
- extracellular region
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phospholipid binding