Brat1 Gene Summary [Rat]
Predicted to be involved in several processes, including positive regulation of cell growth; positive regulation of protein phosphorylation; and response to ionizing radiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human BRAT1 (BRCA1 associated ATM activator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brat1 |
| Official Name | BRCA1-associated ATM activator 1 [Source:RGD Symbol;Acc:1565146] |
| Ensembl ID | ENSRNOG00000001236 |
| Bio databases IDs | |
| Aliases | BRCA1-associated ATM activator 1 |
| Synonyms | BAAT1, Brat1-ps1, BRCA1-associated ATM activator 1, C7orf27, FLJ00053, NEDCAS, RGD1565146, RMFSL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease inhibitor
- HEAT repeat
- protein binding
Pathways
Biological processes and signaling networks where the Brat1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lethal neonatal rigidity and multifocal seizure syndrome
- neurodevelopmental disorder with cerebellar atrophy and seizures
- neurodevelopmental disorder with cerebellar atrophy and with or without seizures
- hereditary disorder
- BRAT1-associated neurodegenerative disorder
role in cell
- apoptosis
- proliferation
- expression in
- growth
- differentiation
- binding in
- DNA damage response
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation of cell growth
- positive regulation of protein phosphorylation
- apoptotic process
- response to DNA damage stimulus
- glucose metabolic process
- mitochondrion localization
- cell migration
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding