Creb3l1 Gene Summary [Rat]
Enables transcription cis-regulatory region binding activity. Involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of transcription by RNA polymerase II; and response to endoplasmic reticulum stress. Predicted to be located in several cellular components, including chromatin; endoplasmic reticulum; and nucleoplasm. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Creb3l1 |
| Official Name | cAMP responsive element binding protein 3-like 1 [Source:RGD Symbol;Acc:1359613] |
| Ensembl ID | ENSRNOG00000005413 |
| Bio databases IDs | |
| Aliases | cAMP responsive element binding protein 3-like 1 |
| Synonyms | C16DELp11.2, cAMP responsive element binding protein 3-like 1, DEL16p11.2, OASIS, OI16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Creb3l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- SMAD binding
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- leucine zipper domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- transmembrane domain
- basic domain
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Creb3l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Calcium Signaling
- Corticotropin Releasing Hormone Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Ephrin Receptor Signaling
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Gαs Signaling
- Hypoxia Signaling in the Cardiovascular System
- IL-10 Signaling
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Synaptic Long Term Potentiation
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- hypertension
- epithelial cancer
- opioid-related disorder
- acute myeloid leukemia
- tubulo-interstitial fibrosis
- osteogenesis imperfecta
- peripheral arterial disease
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
role in cell
- expression in
- proliferation
- production in
- quantity
- size
- cell death
- migration
- morphology
- invasiveness
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Creb3l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of gene expression
- positive regulation of collagen biosynthetic process
- negative regulation of transcription, DNA-dependent
- endoplasmic reticulum unfolded protein response
- osteoblast differentiation
- extracellular matrix constituent secretion
- positive regulation of transcription from RNA polymerase II promoter
- response to endoplasmic reticulum stress
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- cytosol
- endoplasmic reticulum
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding
- protein binding
- SMAD binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity