Serpinb2 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in cornified envelope and extracellular space. Orthologous to human SERPINB2 (serpin family B member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb2 |
| Official Name | serpin family B member 2 [Source:RGD Symbol;Acc:621823] |
| Ensembl ID | ENSRNOG00000002460 |
| Bio databases IDs | |
| Aliases | serpin family B member 2 |
| Synonyms | HsT1201, Monocyte Arg-serpin, ovalbumin, PAI, PAI-2, PAI2A, PLANH2, serine (or cysteine) peptidase inhibitor, clade B, member 2, serpin family B member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- interhelical region
- Serpin (serine protease inhibitor)
- reactive serpin loop
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- acute myeloid leukemia
- advanced cancer
- cancer
- non-insulin-dependent diabetes mellitus
- psoriasis
- epithelial neoplasia
- papillomatosis
- benign neoplasia
- septic shock
role in cell
- proliferation
- phosphorylation in
- migration
- expression in
- adhesion
- cell death
- differentiation
- degradation in
- binding in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- cornified envelope
- Cytoplasm
- intracellular space
- Nucleus
- Plasma Membrane
- granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpinb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- negative regulation of endopeptidase activity
- fibrinolysis
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular space
- cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity