PSMB1 Gene Summary [Human]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PSMB1 |
| Official Name | proteasome 20S subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:9537] |
| Ensembl ID | ENSG00000008018 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit beta 1, proteasome subunit β6 |
| Synonyms | beta 1 PROTEASOME subunit, C5, C81484, HC5, Lmpc5, Macropain subunit C5, NEDMHAL, PMSB1, proteasome 20S subunit beta 1, proteasome 20S subunit β 1, proteasome (prosome, macropain) subunit, beta type 1, proteasome (prosome, macropain) subunit, β type 1, Proteasome Subunit C5, PSB1, PSC5, β 1 PROTEASOME subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- peptidase
- protein binding
- Proteasome subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- T acute lymphoblastic leukemia
- proteinuria
- non-insulin-dependent diabetes mellitus
- endometriosis
- refractory relapsed multiple myeloma
- refractory multiple myeloma
- liver cholangiocarcinoma
- progressive multiple myeloma
- plasma cell myeloma
role in cell
- activation in
- expression in
- cell death
- apoptosis
- quantity
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- cytosol
- secretory granule lumen
- proteasome complex
- proteasome core complex, beta-subunit complex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding