Hoxd13 Gene Summary [Rat]
Enables sequence-specific double-stranded DNA binding activity. Involved in embryonic hindgut morphogenesis; prostate gland development; and response to testosterone. Predicted to be located in nucleoplasm. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in brachydactyly-syndactyly syndrome; clubfoot; cryptorchidism; and dysostosis (multiple). Orthologous to human HOXD13 (homeobox D13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxd13 |
| Official Name | homeo box D13 [Source:RGD Symbol;Acc:1308417] |
| Ensembl ID | ENSRNOG00000001588 |
| Bio databases IDs | |
| Aliases | homeo box D13 |
| Synonyms | BDE, BDSD, homeo box D13, Hox-4.8, HOX4I, SPD, SPD1, spdh |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxd13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- synpolydactyly
- agenesis
- glioblastoma
- glioblastoma cancer
- acute myeloid leukemia
- synpolydactyly 1
- brachydactyly-syndactly syndrome
- dystopia
- brachydactyly type D
- brachyphalangia
role in cell
- proliferation
- expression in
- migration
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxd13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hindgut morphogenesis
- morphogenesis of an epithelial fold
- anterior/posterior pattern specification
- branch elongation of an epithelium
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of branching involved in prostate gland morphogenesis
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- embryonic digit morphogenesis
- skeletal system development
- male genitalia development
- response to testosterone stimulus
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity