Bdh1 Gene Summary [Rat]
Enables 3-hydroxybutyrate dehydrogenase activity and phospholipid binding activity. Involved in several processes, including response to corticosterone; response to estradiol; and response to growth hormone. Located in mitochondrial inner membrane. Biomarker of hyperthyroidism. Orthologous to human BDH1 (3-hydroxybutyrate dehydrogenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bdh1 |
| Official Name | 3-hydroxybutyrate dehydrogenase 1 [Source:RGD Symbol;Acc:620131] |
| Ensembl ID | ENSRNOG00000001736 |
| Bio databases IDs | |
| Aliases | 3-hydroxybutyrate dehydrogenase 1 |
| Synonyms | 2310032J20Rik, 3-HYDROXYBUTYRATE DEHYDROGENASE, 3-hydroxybutyrate dehydrogenase 1, 3-hydroxybutyrate dehydrogenase, type 1, BDH, D-beta-hydroxybutyrate dehydrogenase, D-β-hydroxybutyrate dehydrogenase, SDR9C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bdh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- phospholipid binding
- sepiapterin reductase
- 3-hydroxybutyrate dehydrogenase
- 3-oxoacyl-(acyl-carrier-protein) reductase
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- uterine leiomyoma
- hepatocellular carcinoma
- gastroesophageal reflux
- leiomyomatosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- diabetic nephropathy
- hyperglycemia
regulates
- lipid
- AKT
- LRRC31
role in cell
- expression in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bdh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- 3-hydroxybutyrate dehydrogenase activity