Atp6v1a Gene Summary [Rat]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular response to increased oxygen levels; intracellular iron ion homeostasis; and synaptic vesicle lumen acidification. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1a |
| Official Name | ATPase H+ transporting V1 subunit A [Source:RGD Symbol;Acc:1596464] |
| Ensembl ID | ENSRNOG00000001992 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V1 subunit A |
| Synonyms | AI647066, ARCL2D, ATP6A1, Atp6a2, ATP6V1A1, ATPase, H+ transporting, lysosomal V1 subunit A, ATPase H+ transporting V1 subunit A, ATPase Vacuolar Subunit A, DEE93, HO68, IECEE3, VA68, Vaa1, VATA, Vatpase 70 kd a subunit, V-ATPase V1-A, Vma1, VPP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPsynthase alpha/beta subunit N-term extension
- ATP-synt_F1_V1_A1_AB_FliI_N
- ATP synthase alpha/beta family, nucleotide-binding domain
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- ATP synthase alpha/beta family, beta-barrel domain
- ATPase, FliI/YscN family
- ATP synthase archaeal, A subunit
- V-type (H+)-ATPase V1, A subunit
- ATP-synt_F1_V1_A1_AB_FliI_C
- flagellar protein export ATPase FliI
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp6v1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- infantile or early childhood epileptic encephalopathy 3
- preeclampsia
- hereditary disorder
- autosomal recessive cutis laxa type IID
- cortical visual impairment and intellectual disability
- nephrosis
- infection by Influenza A virus subtype H1N1
role in cell
- survival
- endocytosis by
- homeostasis in
- replication in
- acidification in
- viral entry
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- vesicles
- cytosol
- apical membrane
- nucleoplasm
- growth cone
- secretory granules
- microsomal membrane
- microvilli
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- regulation of macroautophagy
- vacuolar acidification
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- proton-transporting two-sector ATPase complex
- proton-transporting V-type ATPase complex
- secretory granule
- Golgi membrane
- lysosomal membrane
- plasma membrane
- nucleoplasm
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- microvillus
- intracellular membrane-bounded organelle
- membrane
- cytosol
- endosome membrane
- apical plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- hydrogen ion transporting ATP synthase activity, rotational mechanism