Nme1 Gene Summary [Rat]
Enables several functions, including DNA binding activity; gamma-tubulin binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including GTP biosynthetic process; cellular response to glucose stimulus; and response to testosterone. Located in cytoskeleton; mitochondrial outer membrane; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nme1 |
| Official Name | NME/NM23 nucleoside diphosphate kinase 1 [Source:RGD Symbol;Acc:70497] |
| Ensembl ID | ENSRNOG00000002693 |
| Bio databases IDs | |
| Aliases | NME/NM23 nucleoside diphosphate kinase 1 |
| Synonyms | NDPK-A, NM23A, Nm23-h1, NM23-M1, NME/NM23 nucleoside diphosphate kinase 1, Nucleotide diphosphate kinase beta, Nucleotide diphosphate kinase β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nme1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intermediate filament binding
- nucleoside diphosphate kinase
- 3'-5' exonuclease
- protein kinase binding
- nucleic acid binding
- ATP binding
- enzyme binding
- protein binding
- magnesium ion binding
- sequence-specific DNA binding
- identical protein binding
- kinase
- GTP binding
- gamma-tubulin binding
- DNase
- Nucleoside diphosphate kinase family
- single-stranded DNA binding
- double-stranded DNA binding
- NDPk
- ribosomal small subunit binding
Pathways
Biological processes and signaling networks where the Nme1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- expression in
- migration
- motility
- differentiation
- cell death
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- perinuclear region
- Nucleus
- centrosome
- intermediate filaments
- cytosol
- membrane ruffles
- mitochondrial outer membrane
- early endosomes