Neil1 Gene Summary [Rat]
Predicted to enable DNA N-glycosylase activity and lyase activity. Predicted to be involved in base-excision repair; negative regulation of nuclease activity; and response to oxidative stress. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neil1 |
| Official Name | nei-like DNA glycosylase 1 [Source:RGD Symbol;Acc:1306077] |
| Ensembl ID | ENSRNOG00000018577 |
| Bio databases IDs | |
| Aliases | nei-like DNA glycosylase 1 |
| Synonyms | 2810450N13Rik, FPG1, hFPG1, NEH1, NEI1, nei endonuclease VIII-like 1 (E. coli), nei-like DNA glycosylase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Neil1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- lyase
- glycosylase
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme
- protein binding
- Fpg/Nei N-terminal protein domain
- Formamidopyrimidine-DNA glycosylase N-terminal domain
- Endonuclease VIII-like 1, DNA bind
Pathways
Biological processes and signaling networks where the Neil1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- stroke
- gastric cancer
- hepatic steatosis
- obesity
- head and neck squamous cell cancer
- adenomatous polyposis
- ulceration
- osteoarthritis
- infertility condition
role in cell
- survival
- proliferation
- repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Neil1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- base-excision repair
- negative regulation of nuclease activity
- base-excision repair, gap-filling
- depyrimidination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- DNA N-glycosylase activity
- DNA-(apurinic or apyrimidinic site) lyase activity
- damaged DNA binding
- hydrolase activity, acting on glycosyl bonds