Uap1 Gene Summary [Rat]
Enables UDP-N-acetylglucosamine diphosphorylase activity and carbohydrate binding activity. Involved in UDP-N-acetylglucosamine metabolic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uap1 |
| Official Name | UDP-N-acetylglucosamine pyrophosphorylase 1 [Source:RGD Symbol;Acc:1561967] |
| Ensembl ID | ENSRNOG00000002926 |
| Bio databases IDs | |
| Aliases | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| Synonyms | AGX, AGX-1, AGX-2, Antigen X, ESTM38, LOC640502, RGD1561967, SPAG2, UDP-N-acetylglucosamine pyrophosphorylase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphate group acceptor phosphotransferase
- UDP-N-acetylglucosamine diphosphorylase
- UTP--glucose-1-phosphate uridylyltransferase
- enzyme
- carbohydrate binding
- identical protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- productive infection by HIV-1
regulates
- UDP-hexosamine
- UDP-N-acetylglucosamine
- IFN
- UDP-N-acetyl-D-galactosamine
role in cell
- proliferation
- growth
- O-GlcNAcylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon production
- UDP-N-acetylglucosamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- UDP-N-acetylgalactosamine diphosphorylase activity
- UDP-N-acetylglucosamine diphosphorylase activity