Jmjd6 Gene Summary [Rat]
Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; P-TEFb complex binding activity; and transcription regulator activator activity. Predicted to be involved in several processes, including oxidative RNA demethylation; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine; and regulation of RNA metabolic process. Predicted to act upstream of or within several processes, including circulatory system development; hemopoiesis; and recognition of apoptotic cell. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jmjd6 |
| Official Name | jumonji domain containing 6, arginine demethylase and lysine hydroxylase [Source:RGD Symbol;Acc:1305395] |
| Ensembl ID | ENSRNOG00000000250 |
| Bio databases IDs | |
| Aliases | jumonji domain containing 6, arginine demethylase and lysine hydroxylase |
| Synonyms | 5730436I23Rik, D11Ertd195e, jumonji domain containing 6, jumonji domain containing 6, arginine demethylase and lysine hydroxylase, KIAA0585, mKIAA0585, PSR, Ps-R', PtdSerR, PTDSR, PTDSR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Jmjd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- 2-oxoglutarate:oxygen oxidoreductase
- iron ion binding
- enzyme
- protein binding
- single-stranded RNA binding
- identical protein binding
- RmlC-like cupin superfamily
- Cupin-like domain
- RNA binding
- binding protein
- demethylase activity
- histone demethylase activity
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Jmjd6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- epithelial cancer
- neoplasia
- metastasis
- nasopharyngeal cancer
- schizophrenia
- growth failure
- hypoplasia
- early-onset preeclampsia
- organismal death
role in cell
- expression in
- activation in
- binding
- activation
- quantity
- proliferation
- cell viability
- differentiation
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell surface
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Jmjd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- T cell differentiation in thymus
- retina development in camera-type eye
- protein homooligomerization
- sprouting angiogenesis
- cell surface receptor signaling pathway
- erythrocyte development
- mRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- recognition of apoptotic cell
- macrophage activation
- heart development
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- kidney development
- peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
- regulation of nuclear mRNA splicing, via spliceosome
- phagocytosis
- negative regulation of protein homooligomerization
- oxidative RNA demethylation
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone demethylase activity (H4-R3 specific)
- identical protein binding
- protein binding
- peptidyl-lysine 5-dioxygenase activity
- RNA binding
- iron ion binding
- signaling receptor activity
- single-stranded RNA binding
- oxidative RNA demethylase activity
- histone demethylase activity
- histone demethylase activity (H3-R2 specific)